Civil RICO, Protesters, and the First Amendment: A Constitutional Combination

The Racketeer Influenced and Corrupt Organizations Act ( RICO ) provides for both government causes of action and a private cause of action. The private cause of action is usually referred to as civil RICO In recent years, abortion clinics and other groups have used civil RICO in suits against violent protesters. The circuits had disagreed, however, on whether RICO requires the defendant to be economically motivated. The circuits had disagreed, however, on whether RICO. Therefore, abortion clinics and other potential plaintiffs were uncertain whether civil RICO was a viable option in suits against politically or religiously motivated protesters. Although the Court did not address the potential First Amendment issues facing civil RICO,\u27 this Note suggests that civil RICO does not interfere with First Amendment protected expression

On the discrete spectrum of quantum layers

Consider a quantum particle trapped between a curved layer of constant width built over a complete, non-compact, $\mathcal C^2$ smooth surface embedded in $\mathbb{R}^3$. We assume that the surface is asymptotically flat in the sense that the second fundamental form vanishes at infinity, and that the surface is not totally geodesic. This geometric setting is known as a quantum layer. We consider the quantum particle to be governed by the Dirichlet Laplacian as Hamiltonian. Our work concerns the existence of bound states with energy beneath the essential spectrum, which implies the existence of discrete spectrum. We first prove that if the Gauss curvature is integrable, and the surface is weakly $\kappa$-parabolic, then the discrete spectrum is non-empty. This result implies that if the total Gauss curvature is non-positive, then the discrete spectrum is non-empty. We next prove that if the Gauss curvature is non-negative, then the discrete spectrum is non-empty. Finally, we prove that if the surface is parabolic, then the discrete spectrum is non-empty if the layer is sufficiently thin.Comment: Clarifications and corrections to previous version, conjecture from previous version is proven here (Theorem 1.5), additional references include

Genesis of ancestral haplotypes: RNA modifications and reverse transcription–mediated polymorphisms

Understanding the genesis of the block haplotype structure of the genome is a major challenge. With the completion of the sequencing of the Human Genome and the initiation of the HapMap project the concept that the chromosomes of the mammalian genome are a mosaic, or patchwork, of conserved extended block haplotype sequences is now accepted by the mainstream genomics research community. Ancestral Haplotypes (AHs) can be viewed as a recombined string of smaller Polymorphic Frozen Blocks (PFBs). How have such variant extended DNA sequence tracts emerged in evolution? Here the relevant literature on the problem is reviewed from various fields of molecular and cell biology particularly molecular immunology and comparative and functional genomics. Based on our synthesis we then advance a testable molecular and cellular model. A critical part of the analysis concerns the origin of the strand biased mutation signatures in the transcribed regions of the human and higher primate genome, A-to-G versus T-to-C (ratio ~1.5 fold) and C-to-T versus G-to-A (≥1.5 fold). A comparison and evaluation of the current state of the fields of immunoglobulin Somatic Hypermutation (SHM) and Transcription-Coupled DNA Repair focused on how mutations in newly synthesized RNA might be copied back to DNA thus accounting for some of the genome-wide strand biases (e.g., the A-to-G vs T-to-C component of the strand biased spectrum). We hypothesize that the genesis of PFBs and extended AHs occurs during mutagenic episodes in evolution (e.g., retroviral infections) and that many of the critical DNA sequence diversifying events occur first at the RNA level, e.g., recombination between RNA strings resulting in tandem and dispersed RNA duplications (retroduplications), RNA mutations via adenosine-to-inosine pre-mRNA editing events as well as error prone RNA synthesis. These are then copied back into DNA by a cellular reverse transcription process (also likely to be error-prone) that we have called "reverse transcription-mediated long DNA conversion." Finally we suggest that all these activities and others can be envisaged as being brought physically under the umbrella of special sites in the nucleus involved in transcription known as "transcription factories."

Learning from open source software projects to improve scientific review

Peer-reviewed publications are the primary mechanism for sharing scientific results. The current peer-review process is, however, fraught with many problems that undermine the pace, validity, and credibility of science. We highlight five salient problems: (1) reviewers are expected to have comprehensive expertise; (2) reviewers do not have sufficient access to methods and materials to evaluate a study; (3) reviewers are neither identified nor acknowledged; (4) there is no measure of the quality of a review; and (5) reviews take a lot of time, and once submitted cannot evolve. We propose that these problems can be resolved by making the following changes to the review process. Distributing reviews to many reviewers would allow each reviewer to focus on portions of the article that reflect the reviewer's specialty or area of interest and place less of a burden on any one reviewer. Providing reviewers materials and methods to perform comprehensive evaluation would facilitate transparency, greater scrutiny, and replication of results. Acknowledging reviewers makes it possible to quantitatively assess reviewer contributions, which could be used to establish the impact of the reviewer in the scientific community. Quantifying review quality could help establish the importance of individual reviews and reviewers as well as the submitted article. Finally, we recommend expediting post-publication reviews and allowing for the dialog to continue and flourish in a dynamic and interactive manner. We argue that these solutions can be implemented by adapting existing features from open-source software management and social networking technologies. We propose a model of an open, interactive review system that quantifies the significance of articles, the quality of reviews, and the reputation of reviewers

Grass-Finishing High Value Beef: A Pilot Project in Northern United States

This project examined the feasibility of producing USDA Choice beef—without grain-based finishing—through genetic selection and pasture management. Purebred Angus heifers with high-marbling potential and small/medium frame size were born spring 2011. Heifers were allotted to either pasture (grass-finishing) or feedlot (grain-fed) treatments based on liveweight and intramuscular fat content. When reaching market weight (±1,000 lb) heifers were harvested and carcass data was collected. Feedlot cattle were marketed on August 27, 2012. The grass-finished cattle were marketed on November 1, 2012. Starting and end weights were similar for both treatments but feedlot cattle reached market weight 50% faster (3.9 vs 2.1 lb/day). The average intramuscular fat percent was not different at the start of the trial but there was a trend of grain-fed cattle to have greater intramuscular fat. Rib eye area, yield grade, and number grading Choice were numerically higher for feedlot cattle. This project demonstrated that it is feasible to combine high marbling genetics with pasture management to produce Choice beef in Iowa. Grass-finished cattle were able to achieve 2.1 pounds of gain per day and 60% of the grass-finished cattle ultimately graded Choice. Selection of small-framed, high-marbling potential beef cattle is essential because of the relatively low-energy density of the grass-based diet and the limited grazing season. Efforts to improve pasture quality and extend the grazing season would be beneficial to meet this goal